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Gentle process
Healthy, engineered cells recover quickly for downstream applications
Reliable delivery
Transfects even the most challenging cell types with a wide range of payloads
Exceptional performance
High yields of transfected cells that exhibit high proliferative capacity
Streamlined workflow
Easy to optimize with no requirement for specific media, buffers, or chemical additives
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- Small footprint — compact design fits inside a biological safety cabinet or on a laboratory benchtop
- Rapid processing — samples are processed < 10 milliseconds
- Easy to use — plug and play set up – intuitive software user interface, easy to create and edit protocols
- Flexible — process any or all eight samples in one run
- Convenient — includes bar code reader, NFC tag, and other features for run history analysis
T-Rest
The Power of Resting T Cells
Unlike most immune cells, resting T cells exist in a non-activated, quiescent state. Their “resting” state simultaneously protects the cells from stress-related damage during manufacturing and makes them less likely to differentiate prematurely. This leads to improved functional outcomes in gene editing processes, making these cells poised to enable more durable, adaptable, and potent cell therapies for patients in need.
IMPROVE DURABILITY
Preserve cell viability and stemness throughout manufacturing
ENHANCED GENE EDITING
Lower risk of premature differentiation to deliver precise gene modifications
MAXIMIZE SCALABILITY
Leverage fewer passages for more potent products and shortened expansion times
- Persistent Stemness— CellFE’s cell engineering system preserved phenotypic stemness in resting T cells samples after processing. The use of resting T cells also improved the percentage of live edited cells that exhibited immune function when compared to activated T cells.
- Viability and Proliferation — Engineered resting T cells using CellFE workflow retain the capacity for expansion. The engineered samples showed proliferation levels and viability that were comparable with non-engineered and inactive controls.
- Transfection Efficiency — Resting T cells can be transfected with a variety of payloads using CellFE’s optimized workflow. On average, CRISPR-RNP complex transfection of resting T cells reflected >80% efficiency and samples exhibited exceptional viability comparable to nontreated controls.
DEVICES
Ryva™ PUPs
The Ryva™ PUPs are designed for use with the Ryva™ Mechanoporation System. Each PUP includes eight single-use processing units. Samples can be run independently and up to 2 × 106 cells can be processed per processing unit.
Optimize your protocol
The Ryva™ Optimizer PUP consists of processing units with increasing ridge gap sizes and is used to optimize operating parameters to a specific workflow.
Scale with consistency
The standard Ryva™ PUP consists of microfluidic chips of a single ridge gap size and is used for standard transfection protocols once optimal parameters have been established.
Start the conversation
We partner with researchers and developers to streamline your cellular engineering workflows and achieve higher yields of safe, healthy cells. We want to hear from you.
